【摘要】 目的　观察０．５ ％ 聚维酮碘（ＰＶＰ－Ｉ）龈下冲洗后龈下微生物组成的变化，并与０．５％ 洗必太进行对比研究。方法　选取临床诊断为中、重度牙周炎的患者１１ 例，共计４５ 颗患牙，牙周袋深≥４ｍ ｍ 。将含有患牙的不同象限随机分组，分别采用：（１）０．５ ％ ＰＶＰ－Ｉ；（２）０．５％ 洗必太（ＣＨ） ；（３）０．９ ％ 生理盐水５ｍｌ 进行一次性龈下冲洗。冲洗前及冲冼后２４ 小时分别采集龈下菌斑行刚果红染色涂片，高倍视野下（×１００） 观察龈下微生物组成的变化。结果　０ ．５％ ＰＶＰ－Ｉ龈下冲洗２４ 小时后龈下菌细胞密度降低，球菌比率升高，杆菌比率降低（ Ｐ＜ ０．０１），螺旋体比率未见明显改变，与ＣＨ 组间比较无统计学上差异。效果均明显优于生理盐水组。结论　０．５％ ＰＶＰ－Ｉ龈下冲洗短期即可减少龈下微生物的量，并使微生物组成发生有益的转化，与０．５ ％ 洗必太可达到相同的效果。更多还原

【Abstract】 Purpose To observe the effect of PVP-I used in subgingival irrigation. Methods 11 cases of moderate-advanced periodontitis with 45 pockets≥4mm were included.The tooth/teeth per jaw quadrant was/were randomly assigned to receive one of the following medications: (1)0.5%PVP-I; (2)0.5% chlorhexidine(CH)as positive control; (3)0.9% saline as negative control for subgingival irrigation. Subgingival microbial flora was collected onto the slides before and 24 hours after irrigation. The slides were stained 2% congo red and examined under microscope (×100). The density and the constitutional ration of subgingivl flora were counted. Results Treatment with 0.5% PVP-I and Chlorhexidine significantly decreases the density of subgingival flora and the proportion of rods (P<0.01), and increases the proportion of cocci (P<0.01). No change was observed in spirochetes in all groups. No statistical difference was seen between PVP-I and CH groups. Conclusion Subgingival irrigation with 0.5% PVP-I can result in beneficial alterations on the subgingival microflora. It is also possible that PVP-I is more effective in reducing gingival inflammation than chlorhexidine.更多还原