【摘要】 目的　了解重症肝炎患者经Tα1免疫治疗前后外周血中 (TNF -α) ,sIL -2R ,IL -4 ,IL -6,内毒素及T细胞亚群 (CD+ 4,CD+ 8)的变化。方法　采用ELISA方法或合成基质偶氮显色法或链菌素亲生物素过氧化酶连接法检测上述指标。结果　治疗前各项指标较正常值均有明显改变 ,治疗后除sIL -2R和CD+ 4外 ,其他指标基本恢复到正常水平。结论　Tα1是强有力的免疫调节剂 ,能降低TNF -α ,sIL -2R ,IL -6,内毒素及CD+ 8含量 ,提高IL -4水平 ,从而减轻重症肝炎时免疫反应对肝细胞的损伤。更多还原

【Abstract】 Objective To study the changes of TNF-α, sIL-2R, IL-4, IL-6, endotoxin and T cell subtypes in patients with severe hepatitis before and after treatment with Tα1. Methods TNF-α, sIL-2R, IL-4, IL-6, endotoxin and T cell subtypes were measured by using ELISA, azocoloration or Biotin-streptavidin-peroxides staining.Results Patients had abnormal TNF-α, sIL-2R, IL-4, IL-6, endotoxin and T cell subtypes before treatment when compared to those in the controls. Most indexed except sIL-2R and CD + 4 returned close to normal level after treatment.Conclusion Tα1 can decrease the level of TNF-α, sIL-2R, IL-6, endotoxin and CD + 8, while increases IL-4 level, attenuating immune injury of hepatocyte in severe hepatitis patients.更多还原