【摘要】 目的　探讨风湿热的发病机制 ,了解心肌细胞促凝血活性与风湿热发病的关系。方法　用风湿性心脏炎患者的外周血淋巴细胞、血清及A组乙型溶血链球菌膜抗原作为刺激物 ,测定体外培养的人胚心肌细胞促凝血活性 (HPCA)。结果　患者的外周血淋巴细胞能使HPCA明显升高 ;静止期风心病、风湿性关节炎、其他疾病对照组及健康对照组患者的外周血淋巴细胞均无此特性 ,迁延活动型风湿性心脏炎患者的血清及A组乙型溶血链球菌膜抗原对HPCA也无直接影响。结论　HPCA升高参与风湿性心脏炎的发病 ,可能是风湿性心脏炎的特征病理改变———阿少夫小体中纤维素样物质沉积的形成原因。更多还原

【Abstract】 Objective To ferther study the pathogenesis of rheumatic fever.Methods The peripheral blood lymphocytes,sera of 55 patients with rheumatic carditis and a specific antigen from group A streptococcal cell membrane were prepared and used as stimulants to test the heart tissue cell procoagulant activity (HPCA) in culture.HPCA was measured by using a one stage plasma recalcification clotting time.Results The peripheral blood lymphocytes from rheumatic carditis patients can stimulate the procoagulant activity of human heart tissue cell in vitro .But the sera of rheumatic carditis patients and group A streptococcal cell membrane can not increase HPCA.Conclusion The elevation of HPCA may lead to rheumatic carditis,and result in the construction of Aschoff body which is the pathognomonic focal inflammatory lesion of rheumatic carditis.更多还原