【摘要】 目的 探讨卵巢未成熟畸胎瘤（IOT）的临床病理和免疫组化特点。方法 对11例IOT进行临床病理和免疫组化研究并选择6例卵巢成熟畸胎瘤作对照。结果 患者年龄11～39岁,平均22.7岁;病理分级:4例G₁、3例G₂、4例G₃;临床分期:7例Ⅰ期、1例Ⅱ期、3例Ⅲ期;3例患者合并腹膜胶质瘤病。所有患者均经过手术和术后的化疗。随访4～216个月（平均109个月）,10例存活无复发 免疫组化显示6例IOT有AFP阳性反应,阳性区域见于呼吸道上皮、胃肠道上皮、非特异甲单层柱状上皮和肝样组织;三个胚层的组织中均可见Ki-67阳性细胞,且阳性细胞分布以原始神经上皮层为著;p53未见阳性反应。结论 卵巢未成熟畸胎瘤伴有腹膜胶质瘤病的预后良好,AFP分泌来自内胚层上皮。更多还原

【Abstract】 Objective To investigate the clinicopathological and immunohistochemicai features of immature ovarianteratomas (IOT ). Methods Routine histopathological and immunohistochemicai methods were utilized to analyse 11 cases of IOT specimens,and compared with 6 cases of mature ovarian teratomas . Results The average age of IOT was 22.7 years with the range from 11 to 39 years. According to worris scheme,four patients belonged to grade 1,three grade 2,and four grade 3 tumors. Clinically seven patients were at stage 1 ,one stage 11 ,and three stage 111 . Gliomatosis peritonei was discovered at the same time in three patients as the primary tumor. The patients were treated with surgery and combined postoperative chemotherapy. The mean follow-up period was 109 months ( range 4 ~ 216 months ). Ten patients were alive and disease free. Immunohistochemicai study showed that AFP was found postive in 6 cases located at some small foci of respiratory,gastrointestinal,noaspe-cific cubdoid epithelium and liver-like tissues.The distribution of Ki-67 positive nuclei within the primitive neuroectoderm was found significantly most often in all three germ layers.p53 immunoreactivity was negative in all the cases. Conclusions The prognosis for IOT with gliomatosis peritonei is good. AFP was produced from endodermal cells.更多还原