【摘要】 目的　探讨血管紧张素转换酶 ( ACE)基因多态性是高血压病 ( EH)的致病基因 ,还是 EH性肾损害的危险因素。方法　四角分析法研究 ACE基因多态性与 EH的关系 ,采用 PCR方法对比 ,有和无尿微量蛋白增高 ,EH组与对照组 ACE多态性的差异。结果　无论有还是没有 EH家族史的 EH组 ( n=12 2 )和对照组 ( n=10 9) ACE基因插入 /缺失 ( I/D)多态性之间的变化均无显著性差异。伴有尿微量蛋白增高 EH患者收缩压和甘油三脂最高 ,靶器官损害多 ,D等位基因人数也最多。结论　 ACE基因多态性与 EH发生关系不大 ,但 D等位基因可能增加 EH性肾损害的危险更多还原

【Abstract】 Objective:To investigate whether the insertion/deletion(I/D) polymorphism of ACE gene is one of causes in essential hypertension(EH)or risk factor in hypertensive renal damage.Methods:The relationship between the polymorphisms of ACE gene and EH was studied with a fourangle analysis.The polymorphisms of ACE gene among EH with and without increase of microalbuminuria and control groups were compared.I/D polymorphism in intron 16 of the ACE gene was determined by polymerase chain reaction.Results:No significant difference was found in genotype distribution of I/D polymorphism of ACE gene in hypertensive and the control subjects with or without EH family history.Compared with nonmicroalbuminuria hypertensive and the control groups,systolic blood pressure and triglycerides were the highest,targetorgan damage and D allele were the most in hypertensive microalbuminuria group.Conclusion:Although no significant association of EH with polymorphisms of ACE gene was found,D allele could increase the risk of hypertensive renal damage.更多还原