【摘要】 目的　探讨 P糖蛋白 (P- gp)和 p5 3蛋白在结肠腺癌中的表达意义。　方法　应用免疫组织化学方法检测术前未进行化疗的 140例结肠癌组织中的多药耐药基因产物 P- gp和 p5 3蛋白的表达。　结果　 P- gp和 p5 3在结肠癌中的表达分别为 2 3.5 7% (33/ 140 )和 40 % (5 6 / 140 )。P- gp表达与结肠癌的组织学类型、浸润深度和淋巴结转移状况无关 (P>0 .0 5 ) ;而 p5 3除与淋巴结转移状况有关外 (P<0 .0 5 ) ,与组织学类型和浸润深度无关 (P>0 .0 5 )。P- gp在 p5 3阳性的病例中的表达明显高于 p5 3阴性者 (P<0 .0 1)。　结论　 P- gp和 p5 3协同表达于结肠癌组织中 ,可作为结肠癌病人的临床耐药和预后判断的可靠指标更多还原

【Abstract】 Objective\ To investigate the correlation of the co\|expression of p\|glycoprotein(P\|gp) and p53 protein in colon cancers.\ Methods\ One hundred forty patients with colon cancer, which had not been treated by chemotherapy before surgery, were studied for the expression of P\|gp and p53 protein using immunohistochemistry.\ Results\ P\|gp and p53 were 23.57%(33/140) and 40%(56/140) in colon cancers, respectively.\ Correlation was not observed between P\|gp expression and histological grading, invasive depth and lymph node metastases(P>0.05) and p53 expression was not found any correlation with histological grading and invasive depth(P>0.05) except with lymph node metastases(P<0.05) in colon cancers.\ P\|gp expression was significantly higher in p53\|positive than in p53\|negative(P<0.01).\ Conclusion\ It is indicated that the co\|expression of p53 is often associated with P\|gp and is a better predictive factor for clinic chemoresistance and for prognosis in colon cancers.\;更多还原