【摘要】 朊病毒是一种只含蛋白质而不含核酸的蛋白侵染颗粒 ,能造成哺乳动物的脑部病变 ,它是由正常的蛋白错误折叠成致病蛋白而组成的 ,两种结构不同的蛋白 Pr Pc 和Pr PSc来源于同一基因 ,具有相同的氨基酸序列和共价修饰 ,但在某些方面存在着很大的差别。朊病毒的繁殖是通过正常形式蛋白转变为致病形式完成的。朊病毒病的传播具有种属特异性和株系特异性的特点更多还原

【Abstract】 Prions,which can lead to mammal’s encephalopathy ,are infectious protein particles,devoid of nucleic acid and composed exclusively of protein particles.They comprise some abnormal disease causing protein converted from the normal cellular protein by misfolding .The two protein,PrP c and PrP Sc ,with different construction,come from an same gene and have the identical amino acid sequence and modification,but there are some remarkable difference in some aspects.The multiplication of prions is fulfilled by the conversion from mormal cellrlar prion protein to a disease causing form and the transmission of prions is characterized by the species and strain specifility.更多还原