【摘要】 目的　探讨应用卵巢癌抗原 CP2 及卵巢癌抗独特型单克隆抗体 6 B1 1 Ab2 进行血清中相关抗体检测的可行性及临床应用价值 .方法　应用 EL ISA法对 95例恶性卵巢肿瘤、40例良性卵巢肿瘤及 9例子宫内膜异位症患者血清进行卵巢癌相关抗原及抗体的检测 ,并以 5 0例正常女性为对照 .结果　非粘液性卵巢上皮癌抗原阳性率为 10 0 % ,抗体阳性率为 6 6 .7% ,高于粘液性卵巢上皮癌、非上皮性卵巢恶性肿瘤及生殖系统其他恶性肿瘤 ,并且明显高于卵巢良性肿瘤 (P<0 .0 1) .结论　卵巢癌相关抗原及抗体的检测对临床诊断及辅助鉴别诊断有一定实用价值更多还原

【Abstract】 AIM To evaluate the clinical significance and feasibility of detecting serological tumor associated angigen CP 2 and anti idiotypic monoclonal antibody 6B 11 Ab 2 among patients with ovanian tumor. METHODS Sera samples obtained from 95 patients with malignancies, 40 with benign diseases and 9 with endometriosis were collected and tested via ELISA assay. The 50 normal samples were employed ascontrol. RESULTS The positive rate was 100 percent for CP 2 and 66.7% for idiotype respectively among those with non mucinous epithelial carcinomas, which were higher than those with ovarian epithelial mucinous carcinomas, non epithelial ovarian carcinoma and genital malignancies ( P < 0.01 ). CONCLUSION The detection of such tumor associated antigen and idiotype is of some diagnostic and differential value in clinical practice.更多还原