【摘要】 目的 :探讨术后疼痛的产生机制和术后镇痛的进展。方法 :通过文献复习综合阐述国内外近年来对术后疼痛和术后镇痛的研究情况。结果 :中枢和外周敏感性增高是造成术后持久疼痛的主要原因。术后镇痛的目的在于抑制或逆转传入神经冲动引起的中枢神经元兴奋性的改变。结论 :术后镇痛药物的种类和给药方法很多 ,发展趋势是阿片类、NSAID、1 ,2 ,6—IP3、醋氨酚等抗炎止痛药 ,胆硷酯酶抑制剂等多种类 ,多途径的均衡镇痛和超前镇痛更多还原

【Abstract】 Objective: To study the producing mechanism of postoperative pain and postoperative acesodyne. Methods: To review the literatures about the recent study situation of postoperative pain and acesodyne. Results: The elevated sensitivity of center and peripheral is a main reason of postoperative persistent pain. The aim of postoperative acesodyne is to inhibit or reverse the central nervous excitability caused by afferent nervous impetus, but not to get disappearance of physiological and pathological algesia. Conclusions: There are a lot of drugs and administrating ways for killing pain. The trend is to use the anti-inflammation and anodyne including mecons, NSAID and 1, 2, b-IP3-acetaminophen and cholinesterase inhibitor, and to use multiple administering ways.更多还原