【摘要】 目的 :研究缺血性中风脑水肿时 ,颈动脉推注 2 0 %甘露醇对减轻脑水肿的机理及效果。方法 :建立兔急性不完全性脑缺血模型 ,随机分为对照组、非推注组及推注组 (颈动脉推注2 0 %甘露醇 ) ,通过测定脑含水量及观察脑组织病理变化 ,评价脑水肿程度。结果 :推注组脑组织含水量显著低于非推注组 ,其脑组织病理变化亦明显轻于非推注组。结论 :颈动脉推注甘露醇可明显减轻缺血性脑水肿。更多还原

【Abstract】 Objective:To study the effect and mechanism of 20% mannitol injected into carotid on reduction brain edema induced by cerebral ischemia. Methods: The acute and imcomplete cerebral ischemia model was established. Rabbits were randomly divided into the control group, mannitol not injected and mannitol injected group . Water content of the brain and the pathological changes were observed to evaluate the brain edema. Results: Water content of the brain in mannitol group was significantly lower than that in control group (P<0.01). The pathological changes of mannitol group was also lighter as compared with control group. Conclusion: 20% mannitol injected into carotid can mitigate the pathological change of brain edema induced by cerbral ischemia.更多还原