【摘要】 目的　探讨恶性胸腔积液对晚期非小细胞肺癌 (NSCLC)预后生存的影响。方法　根据临床分期及有无胸腔积液将患者分为三组 ,用生存统计中的 Kaplan- Meier表法做出三组生存曲线并比较显著性。结果　无胸腔积液的 B期患者的生存期与有胸腔积液的 B期患者及 期肺癌患者的生存期比较有显著性差异 ,而 B期有胸腔积液的肺癌患者的生存期与 期患者的生存期比较无显著性差异。在单因素及多因素预后分析中 ,胸腔积液均为影响因素。结论　恶性胸腔积液在晚期非小细胞肺癌中是一个影响预后的独立因素更多还原

【Abstract】 Objective To investigate whether pleural effusion in patients with advanced non small cell lung cancer (NSCLC) has an impact on survival.Methods Ninety eight patients were divided into three groups according to their pleural effusion.The Kaplan Meier technique was compared using the log rank test.The Cox proportional hazards regression model was used to confirm the significance of prognostic factor selected by univariate analysis.Results Median survival times for stage Ⅲ B without effusion,stage Ⅲ B with effusion and stage Ⅳ were 13,3, and 3 months respectively,with significant difference among these three groups.But survival time for stage Ⅲ B with effusion was not significantly different from that of stage Ⅳ.Pleural effusion was selected as a prognostic factor in both the univariate analysis and multivariate analysis.Conclusions Pleural effusion in advanced NSCLC is an independent prognostic factor.更多还原