【摘要】 人T淋巴细胞白血病病毒 1型 (HTLV 1)是最早发现的一种RNA肿瘤病毒。利用HTLV 1基因组长末端重复区 (LTR)或膜基因 (env)序列进行系统树分析 ,可分为C、J、WA、CA和M 5个亚型。为了解我国HTLV 1流行区毒株的主要基因型别 ,从福建莆田地区克隆出 3株HTLV 1的env基因。其序列与已知各亚型代表株进行系统树分析 ,结果表明均为C亚型。首次证实了中国大陆HTLV 1C亚型的存在。该地区地处福建沿海 ,近几个世纪以来对海外人口迁徙频繁。这一地区HTLV 1C亚型的存在是否与目前全球性C亚型的分布有关 ,值得进一步研究。更多还原

【Abstract】 The human T cell leukemia/lymphotropic virus type 1(HTLV 1)belongs to the Oncovirinae subfamily of retroviruses. Phylogenetic analysis of the long terminal repeat(LTR)and env gene of HTLV 1 gave a phylogenetic classification of HTLV 1 genotypes into five major molecular subtypes: Cosmopolitan(C), Japanese(J), West African(WA), Central African(CA), and Melanesian(M). In order to understand the major genotype of HTLV 1 prevalent in China, HTLV 1 env gene was amplified by PCR and sequenced from peripheral blood lymphocyts of three HTLV 1 carriers in the Putian region of Fujian Province. Phylogenetic analysis was done with env sequences of three isolates and the representative strains of five major HTLV 1 subtypes. The results showed that all the three isolated HIV 1 strains were grouped into subtype C. Thus, the existence of HTLV 1 subtype C virus in China mainland was firstly confirmed. Since Putian region is located along the coast of Fujian, where oversea emigration have been frequent in recent several centuries, whether it associated with the global dissemination of HTLV 1 subtype C deserves further study.更多还原