【摘要】 目的 :评价国产异环磷酰胺 (IFO)的疗效和副作用。方法 :以国产IFO为主联合化疗 2 1例恶性肿瘤患者 ,至少完成两个疗程。结果 :小细胞肺癌完全缓解 (CR) 2例 ,部分缓解 (PR) 2例 ;非小细胞肺癌PR 3例 ;恶性淋巴瘤CR 2例 ,PR 3例 ;软骨肉瘤PR 2例。副反应主要是骨髓抑制 ,白细胞Ⅲ°下降居多。脱发、恶心、呕吐较轻 ,多为Ⅰ～Ⅱ°。结论 :IFO为主的化疗疗效满意 ,与环磷酰胺无交叉耐药性 ,毒性较低 ,能耐受更多还原

【Abstract】 ?Objective:To evaluate the effect and side effect of ifosfamide(an isocyclophosphamide made in China) in treatment of malignant tumour.Methods:Twenty-one patients with malignant tumour were treated with ifosfamide combination chemotherapy for at least 2 courses.Results:In small cell lung carcinoma complete remission(CR) was seen in 2,part remission(PR) in 2;in non-small cell lung carcinoma CR in 0,PR in 3;in malignant lymphoma CR in 2,PR in 3;in soft bone sarcoma CR in 0,PR in 2.The main side effect was myelosuppression,mainly in Ⅲ° leukopenia.Alopecia,nausea and vomiting was slight,mainly in Ⅰ～Ⅱ°.Conclusions:The effect of ifosfamide combination chemotherapy is satisfactory.Ifosfamide has no cross tolerance with cyclophosphamide,the toxicity of ifosfamide is low. 〔更多还原