【摘要】 目的 :评价大剂量醛氢叶酸 +5FU持续滴注 48小时 (双周疗法 )治疗晚期大肠癌的客观疗效及毒副反应。方法 :本临床研究采用大剂量醛氢叶酸 +5FU持续滴注 48小时 ,每两周重复一次 (双周疗法 )的方案治疗5 2例晚期大肠癌病人 ,所有病人均接受 4疗程化疗。结果 :CR 2例 ,PR 15例 ,NC 18例 ,PD 17例 ,有效率为32 6 9%。病人的主要毒副反应为外周静脉炎、粘膜炎、腹泻、恶心和呕吐、骨髓抑制、脱发等。除外周静脉炎较严重外 ,其余毒性均为Ⅰ～Ⅱ度 ,病人耐受良好。结论 :大剂量醛氢叶酸 +5FU持续滴注 48小时 (双周疗法 )治疗晚期大肠癌疗效较好 ,方案是安全的 ,病人耐受性良好 ,值得在临床上推广使用。更多还原

【Abstract】 Objective: To evaluate the objective anti tumor efficacy and safety of high dose Leucovorin plus 5 flouruoracil continuous infusion in the treatment of advanced colorectal carcinoma Methods: Fifty two patients with advanced colorectal carcinoma were treated with high dose Leucovorin plus 5 flouruoracil 48 hours continuous infusion and then repeated every 2 weeks (Biweek schedule) All patients received at least four cycles of chemotherapy Result: There were two CR, fifteen PR, eighteen NC and seventeen PD in this series with total response rate of 32 69% The main side effects include peripheral phlebitis, mucositis, diarrhea, nausea and vomiting, bone marrow suppression, and alopecia All the side effects were tolerable and mild except for peripheral phlebitis Conclusion: High dose Leucovorin plus 5 flouruoracil continuous infusion is a safe and effective therapy for patients with advanced colorectal carcinoma更多还原