【摘要】 目的 :探讨 1.5—二氨基蒽醌 (1.5 -DAAQ)、1 5—二氯蒽醌 (1 5—DCAQ)和 1 8—二氯蒽醌 (1 8—DCAQ)的遗传毒理。方法 :本文运用小鼠外周血淋巴细胞微核测定方法。结果 :小鼠第一次被注射 1 5—DAAQ ,1 5—DCCQ和 1 8—DCAQ所产生的微核细胞与空白对照组相比无显著性差异 ,第二次以及以后各次分别注入上述三种化合物时 ,与对照组相比有显著差异 (P <0 0 1)。结论 :三种AQs在小鼠体内累积到一定数量时 ,会产生明显的遗传毒性。更多还原

【Abstract】 Purpose and Methods: Most of the information about possible genotoxic effects of anthraquinone derivatives is derived from prokaryotic systems that must differ from mammalian systems and human. In this study 1.5-diaminoanthraquinone(1.5-DAAQ), 1.5-dichloroanthraquinone(1.5-DCAQ) and 1.8-diahloroanthraquinone(1.8-DCAQ) were selected for testing used micronucleus(MN) analysis in BALBC/c mice peripheral blood lymphocytes. Results: Results show that they were significant difference from second to fifth injection times as compared with the control micronucleus frequency (P<0.01) when those compounds accumulated to a weight of 100mg/kg.bw following ip in BALBC/c mice. Conclusion: We suggest there is requirement to research and minitor their mutagenesis.更多还原