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养胃冲剂对大鼠萎缩性胃炎胃粘膜组织形态及胃肠激素的影响
The Influence of Yangwei Granule on the Structure of Gastric Mucosa and Plasma in Rat Models with Chronic Atrophic Gastritis
【摘要】 用甲硝基亚硝胍加酒精建立大鼠慢性萎缩性胃炎模型, 观察养胃冲剂对其胃粘膜组织病理学、前列腺素 E2 ( P G E2) 、生长抑素 ( S S) 、血浆胃动素 ( M O T) 的影响。结果造模大鼠经治疗胃粘膜光镜下 组织学明显改变, P G E2 、 S S 水平升高, 与造模组对比, 有显著性 差异 ( P< 0 .05) ; 血 浆 M O T 浓度 无显著 性差异 ( P> 0 .05) 。说明养胃冲剂可调节胃肠道激素分泌, 起到保护胃粘膜、修复损伤胃粘膜的治疗作用。
【Abstract】 Setting up rat model of chronic atrophic gastritis(CAG) by using Methylnitronitrosoguanidine(MNNG) and alcohol,to observe the effect of Yangwei Granule(YWG)on gastric mucosa,prostaglandin E 2(PGE 2),somatostatin(SS) and plasma Motilin(MOT).Results:YWG could alter the structure of gastric mucosa,increase the level of PGE 2 and SS as compared with the control group ,the difference being significant (P< 0.05), while that of MOT was not significant(P> 0.05). Conclusion:YWG can protect the gastric mucosa and repair its damage by regulating the secretion of gastrointestinal hormone.
【Key words】 Yangwei Granule/pharmacol.; Gastritis,atrophic/TCD ther.; Animal disease model;
- 【文献出处】 中药新药与临床药理 ,TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY , 编辑部邮箱 ,1999年05期
- 【分类号】R259.73
- 【被引频次】19
- 【下载频次】151