【摘要】 本文以柯萨奇病毒B₃（CVB₃）感染Balb/c小鼠建立心肌炎模型,检测了小鼠脾脏中T细胞亚群。结果显示,病毒感染后5天,脾脏中Thy1,2⁺（T总）增高,7～15天降低,第21天恢复正常。L3T4⁺（Th/Ti）于病毒感染后7天开始增高,直到21天均明显高于对照组。lyt 2⁺（Tc/Ts）于病毒感染后5-21天均明显高于对照组,结果提示,病毒感染本身和T细胞介导的免疫均参与病毒性心肌炎的发病。更多还原

【Abstract】 In this study, we established viral myocarditis model by using coxsackie virus type B3 inoculation. Results of the study revealed the following: 5 days after inoculation, the percentage of Thy1,2+ cells in the spleen of infected mice was increased, then it was decreased significantly on days7-15 and 21 L3T4+ subsets were increased on 7 days and 21 lyt2+ subsets were increased on days 5, and 21 Myocardiac necrosis and inflammatory cell infiltration became more and more severe from 5 days to 21 days. The results indicate that T lymphocyte subsets may be associated with viral myocarditis.更多还原