【摘要】 目的：了解日达仙（Tα1）的免疫调节作用。方法：选择18例重型肝炎患者，用Tα1治疗，1.6mg／次，SC，隔日一次，28d为一疗程。在治疗前后检测内毒素（LSP）、肿瘤坏死因子（TNF）、白细胞介素-2受体（IL-2R）、白细胞介素-4（IL－4）、白细胞介素-6（IL－6）及T细胞亚群（细胞，细胞）。结果：治疗前LSP，TNF，IL－2R，IL－6均增高（P＜0．01），而IL－4及细胞降低。经Tα1治疗后，LSP，TNF，IL－2R，IL－6，T细胞均降低（P＜0.01），而IL－4及CD增高。结论：Tα1是一种强有力的免疫调节剂，能降低LSP，TNF，IL-2R，IL－6，T细胞，提高IL－4水平，从而减轻重型肝炎肝细胞的免疫损伤。更多还原

【Abstract】 To observe the immunoregulatory effect of thymosin αl (Tα1 ).METHODS: 18 patients with sever hepatitis were treated with 1. 6 mg Tα1 every two-days for 28 days.The serum level of LSP, TNF, IL-2R, IL-4, IL-6, and CD4T and CD8T cells were measured before and after treatment. RESULTS: After treatment, the serum level of LSP, TNF, IL-2R, IL-6, and CD8Tcells were decreased and the IL-4 serum level and CD4T-cells amount were increased. CONCLUSION:Tα1 is a potent immunoregulatory agent and the immunodamage of liver cells in severe hepatitis patients can be reduced by it.更多还原