【摘要】 目的：评价腺苷蛋氨酸治疗急、慢性病毒性肝炎的疗效。方法：选择急性病毒性肝炎患者22例、慢性病毒性肝炎患者40例作为治疗组，选择病情相同的急性肝炎11例，慢性病毒性肝炎20例为对照组。治疗组用腺苷蛋氨酸．其中急性肝炎组1g／d，静脉滴注，疗程2周，慢性肝炎组1g／d，静脉滴注，疗程4周。对照组用中药茵栀黄治疗，其中急性肝炎组30ml／d，静脉滴注，疗程2周，慢性肝炎组30ml／d，静脉滴注，疗程4周。两组其他治疗相同。治疗前及治疗后定期检测肝功能指标。比较各组治疗前后肝功能指标变化，并对两组治疗前后的差值进行比较。结果：急性肝炎两组治疗后肝功能指标有明显改善，与治疗前比较均有显著性差异（P＜0．05），但两组治疗前后差值均数比较则没有显著性差异（P＞0．05）。慢性肝炎两组治疗后肝功能指标有明显改善，与治疗前比较均有显著性差异（P＜0．05），治疗组治疗前后总胆红素（TBil）及直接胆红素（DBil）差值与对照组治疗前后TBil及DBil差值相比有显著性差异（P＜0．05），治疗组TBil和DBil较对照组下降快，余肝功能指标变化两组没有差异（P＞0．05）。结论：腺苷蛋氨酸是一种治疗肝炎有效的药物，能有助于消除肝内胆汁郁积。更多还原

【Abstract】 ： To evaluate the therapeutic effect of S-adeanosyl methionine (SAMe) in treatment of acute and chronic viral hepatitis. METHODS: 33 patients with acute viral hepatitis and 60 patients with chronic viral hepatitis were divided into treatment group (22 patients with acute patients and 40 patients with chronic patients) and control groups (11 patients with acute patients and 20patients with chronic patients). Patients were treated with intravenous SAMe 1g/d for 2 weeks in acute treatment group and for 4 weeks in chronic treatment group. Patients in the control groups were treated with intravenous yin-zhi-huang, 30 ml/d for 2 weeks in acute group and 4 weeks in chronic group. The hepatic functions after treatment were compared with those before treatment. RESULTS:The liver function in both acute treatment and control groups (P >0. 05 ) was improved after treatment but no significant difference in therapeutic effect between groups and the total and direct bilirubin in chronic patients were decreased more rapidly in active groups than those of control group (P <0. 05 ). CONCLUSION: SAMe is an effective agent for treatment of viral hepatitis especially in reducing intrahepatic cholestasis.更多还原