【摘要】 目的　探讨非癌性肺组织 Ｐ糖蛋白的表达情况及肺癌原发灶与肺癌淋巴结转移灶中 Ｐ糖蛋白表达的关系。　方法　采用免疫组织化学标记链亲和素生物素法检测１６ 例非癌性肺组织、４１ 例肺癌原发灶及肺癌淋巴结转移灶中 Ｐ糖蛋白的表达情况。　结果　１６ 例非癌性肺组织中， Ｐ糖蛋白的阳性表达率为１２．５％ （２／１６）。肺癌原发灶 Ｐ糖蛋白阳性表达２７ 例中，其淋巴结转移灶 Ｐ糖蛋白阳性表达２１ 例（７７．８％ ），阴性表达６ 例；原发灶 Ｐ糖蛋白阴性表达１４ 例中，其淋巴结转移灶均无阳性表达。肺癌淋巴结转移灶 Ｒ糖蛋白的表达与肺癌原发灶 Ｐ糖蛋白的表达有关（ Ｐ＜ ０．０１）。　结论　 Ｐ糖蛋白在非癌性肺组织中也有表达，但阳性表达率较低。肺癌原发灶与肺癌淋巴结转移灶中 Ｐ糖蛋白的表达有关，原发灶阳性表达者，其转移性淋巴结多数亦呈阳性表达；原发灶阴性表达者，其转移性淋巴结均呈阴性表达。更多还原

【Abstract】 Objective To study the expression of P glycoprotein in human non cancerous lung tissue and the resected lung tissue sample of patients with non cancerous lung disease and the correlation between the expression of P glycoprotein in the primary lesion and in the metastatic lymph node of patients with lung cancer. Methods The expression of P glycoprotein in the resected sample of 16 patients with benign lung disease and 41 patients with regional lymph node metastasized lung cancer were detected by immunohistochemistry. Results In 16 patients with benign lung disease, 2 patients had positive expression(positive ratio 12.5%). In 41 patients with lung cancer, 27 patients had positive expression in primary lesion, among these 27 patients, 21 patients showed positive expression in metastatic lymph node and the other six show negative expression of P glycoprotein in primary lesion,among the other 14 patients who showed negative expression of P glycoprotein in primary lesion, no one showed positive expression in metastatic lymph node. Conclusion Patients with benign lung disease also show positive expression of P glycoprotein in the resected lung tissue, but the positive ratio was very low.In the patients with lung cancer, the expression of P glycoprotein in the metastatic lymph node correlated with the expression in the primary lesion.更多还原