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重组链激酶在重度脑室内出血外科治疗中的应用

The local use of recombinant streptokinase in surgical treatment of severe intraventricular hemorrhage.

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【作者】 张义陈衔城吴劲松宋后燕任军

【Author】 Zhang Yi, Chen Xianheng, Wu Jinsong, Song Houyan, Ren Jun, Department of Neurosurgery, Huashan Hospital. Shanghai Medical University, 12 Wulumuqi Zhong Road, Shanghai. 200040. Tel:021 62489999 511

【机构】 上海医科大学华山医院神经外科

【摘要】 目的研究重组链激酶(rSK)在脑室内出血治疗中的应用。方法对15例重度脑室内出血(IVH),于发病后16小时内进行双侧或单侧脑室外引流术,并辅以rSK脑室内纤溶治疗。结果CT复查示,14例于术后4日脑室内积血减少约60%,7例积血1周内完全消失,7例于2周内消失,1例死亡,随访13例中优良11例,脑积水3例行脑室腹腔分流术。结论早期脑室外引流及应用rSK纤溶治疗重度IVH效果良好,无明显副反应发生。

【Abstract】 s Objective The local use of recombinant streptokinase (r SK) in the treatment of severe intraventricular hemorrhage (IVH) was studies. Methods Fifteen cases with severe intraventricular hemorrhage were treated with r SK injected into the lateral ventricle followed by ventricular drainage which was performed within 16 hours after onset. A total dose of r SK was 15 mg in each case.Results CT showed that the ventricular clots of 14 cases were decreased about 60 percent at 4th day after treatment. There were 7 cases whose ventricular clots disappeared on the CT scan the first week after the treatment and another 7 cases clots disappeared after two weeks. Only one patient died. In follow up 11 of 13 pationts showed excellent or good recovery. Three patients developed hydrocephalus and got ventricular peritoneal shunt. There were no hemorrhage, infection or other complications after the treatment with r SK.Conclusions The treatment may contribute to an improvement of prognosis for the patients with severe IVH.

  • 【文献出处】 中国神经精神疾病杂志 ,CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES , 编辑部邮箱 ,1999年03期
  • 【分类号】R743.340.5,R743.340.
  • 【被引频次】15
  • 【下载频次】26
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