【摘要】 目的探讨日本血吸虫未成熟卵可溶性抗原（ＳＩＥＡ）诱导保护性免疫的效果及机制。方法将日本血吸虫未成熟卵在ＲＰＭＩ—１６４０培养液加ＳＩＥＡ免疫血清中培养４天，小鼠尾静脉注射该虫卵，３２天后观察并统计小鼠肺内肉芽肿面积。结果对照组和实验组肺内虫卵肉芽肿面积之间存在显著性差异（Ｐ＜０．０１）。结论ＳＩＥＡ诱导产生的抗体具有一定的免疫力；抗体可能通过阻塞卵孔或者结合特定抗原，阻止卵内毛蚴发育，达到抗卵胚发育的效果。更多还原

【Abstract】 Aim Study on the effect and mechanism of the immunity induced by Schistosoma japoincum soluble immature egg antigen(SIEA).ZMethods The immature eggs after being cultured with RPMI-1640 containing anti-SIEA serum or control serum were injected into the mice through tail vein. Results 30 days later,there was obvious difference region of granuloma in lung between the two groups. Conclusion The results indicated that SIEA could induce incomplete immunity.Antibody may occlude pore of eggs or combine special antigen to impede development of miracidia or egg maturation.更多还原