节点文献

SIEA抗血清抑制日本血吸虫卵肺肉芽肿的研究

THE SIUDY OF SIEA ANTISERA EFFECT ON INHIBITING SCHISTOSOMA JAPONICUM GRANULOMA FORMATION IN LUNG

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 董惠芬杨明义余祖江蒋明森杨孟祥

【Author】 Dong HuifenYang MinyiYu Zujianget al (Department of Parasitology,Hubei Medical University,Wuhan 430071)

【机构】 湖北医科大学寄生虫学教研室

【摘要】 目的探讨日本血吸虫未成熟卵可溶性抗原(SIEA)诱导保护性免疫的效果及机制。方法将日本血吸虫未成熟卵在RPMI—1640培养液加SIEA免疫血清中培养4天,小鼠尾静脉注射该虫卵,32天后观察并统计小鼠肺内肉芽肿面积。结果对照组和实验组肺内虫卵肉芽肿面积之间存在显著性差异(P<0.01)。结论SIEA诱导产生的抗体具有一定的免疫力;抗体可能通过阻塞卵孔或者结合特定抗原,阻止卵内毛蚴发育,达到抗卵胚发育的效果。

【Abstract】 Aim Study on the effect and mechanism of the immunity induced by Schistosoma japoincum soluble immature egg antigen(SIEA).ZMethods The immature eggs after being cultured with RPMI-1640 containing anti-SIEA serum or control serum were injected into the mice through tail vein. Results 30 days later,there was obvious difference region of granuloma in lung between the two groups. Conclusion The results indicated that SIEA could induce incomplete immunity.Antibody may occlude pore of eggs or combine special antigen to impede development of miracidia or egg maturation.

  • 【文献出处】 中国人兽共患病杂志 ,CHINESE JOURNAL OF ZOONOSES , 编辑部邮箱 ,1999年04期
  • 【分类号】R457.2
  • 【被引频次】1
  • 【下载频次】36
节点文献中: 

本文链接的文献网络图示:

本文的引文网络