【摘要】 目的探讨血清急性时相蛋白对胃、大肠癌预后的判断作用。方法对１５０例胃癌和大肠癌患者手术前后血清急性时相蛋白（α１ＡＧ，α１ＡＴ，ＣＲＰ）浓度进行动态观察。结果１５０例胃癌、大肠癌患者术后血清α１ＡＧ，α１ＡＴ，ＣＲＰ浓度比术前明显降低（Ｐ均＜０．００１），其中１０２例行根治术的术后血清α１ＡＧ，α１ＡＴ，ＣＲＰ浓度比４８例行姑息术的术后下降更为明显（Ｐ＜０．０１）。１０２例根治手术后随访，３４例术后复发者血清α１ＡＧ，α１ＡＴ，ＣＲＰ浓度比未复发者明显升高（Ｐ＜０．００１）。结论血清α１ＡＧ，α１ＡＴ，ＣＲＰ可作为胃癌和大肠癌的负荷指标，动态观察其浓度变化，对了解胃癌和大肠癌转移程度，手术疗效评价以及判断预后具有一定意义。更多还原

【Abstract】 Objective To explore the effect of acute phase proteins on evaluating the prognosis of patients with coloractal cancer (CRC) and gastric cancer (GC). Methods Serum concentrations of α 1 antitrypsin (α 1 AT), α 1 acid glycoprotein (α 1 AG) and C reactive proteion (CRP) were observed in 150 patients with colorectal cancer and gastric cancer before and after operation. Results Serum concentrations of the three proteins in patients after operation were significantly lower than those in patients before operation ( P <0.001); postoperative serum concentrations of the three proteins in 102 patients who underwent radical operations were significantly lower than those in 48 patients who were subjective to palliative operation ( P <0.001). The 102 patients with radical operation were followed up. Of them, 34 patiens recurred. Serum concentrations of the three proteins were significantly higher in patients with recurrence than those in patients with non recurrence ( P <0.001). Conclusions Combined examination of the three indexes can help to evaluate the curative operation effect and postoperative recurrence in patients with CRC and GC. It may be one of the biological indicators for predicting metastasis, effect of operation and prognosis in patients with CRC and GC.更多还原