【摘要】 为探讨抑癌基因ｐ１６ 、癌基因Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 在胰腺癌中的作用及其相互关系，应用免疫组织化学方法检测了ｐ１６ 、Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 基因在胰腺癌中的表达。结果：ｐ１６ 在胰腺癌中为低表达，Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 呈过度表达；ｐ１６ 与Ｃｙｃｌｉｎ Ｄ１ 呈负相关关系（ Ｐ＜ ０ ．０５） ，Ｃｙｃｌｉｎ Ｄ１ 与ＣＤＫ４ 呈正相关关系（ Ｐ＜ ０ ．０５） 。提示胰腺癌发生机理涉及ｐ１６ 、Ｃｙｃｌｉｎ Ｄ１ 和ＣＤＫ４ 基因的异常，ｐ１６ 低表达和Ｃｙｃｌｉｎ Ｄ１ 高表达在胰腺癌发生中起协同作用。更多还原

【Abstract】 To study the mechanism of p16,Cyclin D 1 and CDK4 and their relationship with pancreatic carcinoma, their expressions were examined by immunchistochemistry methods. Results: overpression of Cyclin D 1 and CDK4 was revealed in these samples and p16 was undertectable. There was a negitive correlation between p16 and Cyclin D 1 ( P <0.05), and a positive relation between Cyclin D 1 and CDK4 ( P <0.05). The results indicate that abnormality of p16, Cyclin D 1 and CDK4 may be involved in the molecular mechanism of pancreatic carcinoma, p16 lower expression and Cyclin D 1 over expression may coexit in the development of pancreatic carcinoma.更多还原