【摘要】 目的探讨乳腺癌及其癌旁组织的分子生物学关系以进一步研究乳腺癌的可能癌变机制。方法用流式细胞仪检测２６例乳腺癌及其癌旁组织的ＤＮＡ倍体、增殖指数（ＰＩ）及ｂｃｌ－２表达并进行了统计学对比分析。结果３例癌旁组织发现异倍体，其所对应的癌组织亦为异倍体。而双倍体肿瘤组织其癌旁组织无异倍体发现。癌组织的异倍体表达率（５７．７％）及ＰＩ值与其癌旁组织均有显著性差异（Ｐ＜０．０５），ｂｃｌ－２表达在癌组织及其癌旁组织间无显著性差异（Ｐ＞０．０５）。结论癌旁组织具有恶变趋势，ＦＣＭ可以作为病理诊断的补充。ｂｃｌ－２与乳腺癌的确切关系有待于进一步研究。更多还原

【Abstract】 Objective To study the molecular biological relation between breast cancer tissue and its para cancer tissue, and to explore the mechanism of breast canceration furthur . Methods DNA content, proliferative index (PI) and bcl 2 were measured on cancer tissues and para cancer tissues from 26 cases of breast cancer with flow cytometry.Results Our results showed that the incidence of aneuploidy in paracancer tissues(3 cases) depended on their primary cancer tissues,and no aneuploidy was detected in para cancer tissues with diploid primary cancer.The ratio of aneuploidy of cancer tissues(57.7%) and PI were obviously higher than those of para cancer tissues(P<0.05).bcl 2 expression has no significant difference between cancer tissue and para cancer tissue(P<0.05).Conclusion Our study suggests that para cancer tissue has the potentiality of canceration.FCM could be a supplementary method for pathological diagnosis. We think that the real relation between breast cancer and bcl 2 should be studied further.更多还原