【摘要】 目的　探讨核的形态参数在膀胱移行细胞肿瘤诊断与鉴别诊断中的作用，为计算机辅助病理诊断积累资料。方法　采用图像分析系统对膀胱慢性炎、内翻性乳头状瘤、移行细胞乳头状瘤（以上称非癌性病变）、移行细胞癌（ＴＣＣ）Ⅰ级、Ⅱ级、Ⅲ级各５ 例及尸检正常移行上皮２ 例的核形态参数，（包括核面积、核周长、核形状因子、等效核直径、核质比和核黑度）进行测量。结果　核面积、核周长、等效核直径和核质比四项指标，良恶之间比较均有高度显著性差异，且ＴＣＣⅢ＞ ＴＣＣⅡ＞ ＴＣＣⅠ＞ 非癌性病变。结论　这些参数在良恶鉴别和移行细胞癌的分级中有一定价值；移行细胞癌恶性程序的增高主要表现为细胞核的增大和大小悬殊；图像分析为移行细胞肿瘤的数学病理学研究提供了一定资料。更多还原

【Abstract】 Objective To evaluate some nuclear parameters in diagnosis and didfferential diagnosis in order to establish a computer diagnosing system.Methods With the image analysis system,cells were studied for their nuclear area,nuclear perimeter,nuclear regular form factor,nuclear equivalent diameter,nuclear darkness and the ratio of nuclear area to cytoplasmic area in five cases of chronic cystitis,inverted papilloma,transitional cell papilloms,transitional cell carcinoma Ⅰ,Ⅱ,Ⅲ grade and two cases of nomal transitional epithelium.Results Highly significant statistical difference was detected in four parameters between benign and malignant cases.Conclusion Nuclear area,nuclear perimeter,nuclear equivalent diameter and the ratio of nuclear area to cytoplasmic area are more valuable in diagnosis and differential diagnosis.The higher the morphologic grade of malignancy is,the bigger the nuclei is.Morphometric analysis provides datas for the study of quantitaive histopathology更多还原