【摘要】 本研究用免疫组化法检测了食管癌高发区人群中不同食管病变抗癌基因Ｐ５３、癌基因ＥＧＦｒ蛋白的表达，并进行了随访研究。结果显示：从正常上皮到浸润癌的各级病变中，Ｐ５３蛋白呈增长趋势。一组不典型增生病人随访２４个月的重复检测表明，无论阳性或阴性表达，形态学未发现有进展为癌的倾向。２０例早期食管癌的检测和３３～７８个月的随访结果显示，肿瘤基因的阳性表达与预后有明显的关系。更多还原

【Abstract】 The expression of P 53 and EGFr was assyed immunohistochemically in biopsy specimens of early esophageal lesions obtained from high risk population for esophageal cahcer,and a follow up study was performed.The results showed that positive expression of P 53 protein gradually increased from normal esophageal mucosa,to basae cell hyperplasia,to dysplasia,and finally to advanced carcinoma.Nocancer was found in patients with dysplasia during the follow up period of 24 monthes whether the expression of oncogen is positive or not.the expression of P 53 and EGFr in 20 patients with early esophageal cancer and its relationship to prognosis were inrestigated.Follow up was carried out for 33～78 months,and the results suggest that the expression of P 53 and EGFr may be a valuable parameter for predicting the prognosis.更多还原