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EB病毒ZEBRA lgG抗体变化规律和鼻咽癌发病的关系

The Relationship between EB Virus ZEBRA/igG Change Regulation and Nasopharyngeal Carcinoma

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【作者】 曹素梅黄腾波简少文柳青

【Author】 CAO Su mei,HUANG Teng bo,JIAN Shao wen,et al Cancer Institute,Sun yat Sun University,Guangzhou 510060

【机构】 中山医科大学肿瘤中心中山医科大学

【摘要】 目的 研究ZEBRAIgG 在鼻咽癌癌变不同阶段的动态变化规律。方法 对四会地区鼻咽癌筛查人群的血清库不同时期的标本用ELISA 法检测ZEBRAIgG,包括:鼻咽癌27 例,高危人群50 例,单阳人群50 例,全阴人群30 例。结果 鼻咽癌组ZEBRAlgG的阳性率为90-9% ,高于各对照组,差异均有显著性(P<0-01) 。从ZEBRAIgG出现阳性至病理确诊时的时间平均为3-5(2-62~4-38) 年,且至病理确认时抗体水平逐渐升至最高。结论 ZEBRAIgG可作为一个诊断鼻咽癌的指标,抗体持续高水平或抗体水平持续升高者应高度怀疑鼻咽癌。

【Abstract】 Objective to explain the change regulation of ZEBRA/IgG in the different state of nasopharyngeal canceration.Methods ZEBRA/IgG were detected in ELISA method to the different state screening samples in suihui area.including:nasopharyngeal carcinoma 27,high risk people 50,VCA/IgA positive person 50,all negative person 30. Results The positive rate of ZEBRA/IgG in the group of NPCwre 90 9%,which is higher than the contrast groups.There is significance between them(P<0 01).The average time from ZEBRA/IgG first positive to be pathonalagly diagnosised is 3 5(2 62 4 38)years and the titer of the antibody gradually rise to the highest level.Conclusion The study suggested that ZEBRA/IgG might be as a diagnosis marker to NPC.The patients whose ZEBRA/IgG consistly keep high or rise should be highly suspected of NPC.

【关键词】 鼻咽癌ZEBRAIgGEB病毒
【Key words】 Nasopbaryngeal cancerationZEBRA/IgGEB virus
  • 【文献出处】 肿瘤防治研究 ,CANCER RESEARCH ON PREVENTION AND TREATMENT , 编辑部邮箱 ,1999年05期
  • 【分类号】R739.63
  • 【被引频次】3
  • 【下载频次】86
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