【摘要】 本文对６１例手足徐动型脑瘫儿童应用美多巴的临床效果、不良反应、用药剂量、加量间隔、用量与效果的关系进行了研究。结果显示：以脑瘫儿童日常生活能力评价表作为疗效评价标准，用美多巴治疗组与不用美多巴治疗组在第３次评价时有极显著性的差异（Ｐ＜０．００１）。因此说明用美多巴治疗是有效的，而其不良反应轻且短暂。平均开始用量为９ｍｇ／ｋｇ／ｄ，最大开始用量可达２６ｍｇ／ｋｇ／ｄ，平均间隔一周后加量，最短间隔一天，可加量至２０ｍｇ／ｋｇ／ｄ，最大可加量至３８ｍｇ／ｋｇ／ｄ，用量与效果不存在相关性。本文对今后的研究也提出了建议。更多还原

【Abstract】 In this paper,we studied the clinical effects,side effects,doses ,dosing interval,relations between doses and effects of using Madopar in 61 children with athetoid cerebral palsy.Taking ADL Evaluation Scheme for Cerebral Palsied Children as main efficacy value,very marked statistic difference exists when two groups with or without Madopar were assessed on the third evaluation in our study,and it shows the effects of Madopar while its adverse events are mild and transient.The average and maximal initial dose is 9mg/kg/d and 26mg/kg/d respectively,and the average titration interval is one week while the shortest inetrval is a day.It can be titrated to 20mg/kg/d on average and 38mg/kg/d on maximal dose.There was no correlation between doses and effects.Suggestion was made for further investigation.更多还原