【摘要】 目的　比较地氟醚对血液动力学和儿茶酚胺的影响。方法　择期手术病人３０ 例（ＡＳＡⅠ～Ⅱ） ，随机分为地氟醚（１５ 例）、异氟醚（１５ 例）两组。不用术前药。气管插管后观察不同ＭＡＣ时地氟醚和异氟醚对ＭＡＰ、ＨＲ和血中儿茶酚胺浓度的影响。结果　在地氟醚组达１－５ ＭＡＣ后呈现２～４ ｍｉｎ 的血压增高和心率增快，且儿茶酚胺增高。结论　快速增加地氟醚浓度至１－５ＭＡＣ可出现交感兴奋作用，而异氟醚没有此作用。更多还原

【Abstract】 Objective To compare the effects of desflurane and isoflurane on hemodynamics and catecholamine. Methods Thirty patients (ASAⅠ～Ⅱ grade),scheduled for elective surgery requiring general anesthesia were studied ,randomly divided into two groups :desflurane group (group A, n=15),isoflurane group(group B,n=15).After facilitated tracheal intubation ,anesthesia was maintained with 0.5 MAC desflurane or isoflurane in oxygen .After 15min at 0.5MAC,rapid increasing the end-tidal concentration to 1.0 MAC and 1.5 MAC,and maitained these concentration each for 5 min .During anesthesia wash in ,O 21L/min,vaporizer instituted at 18%(Des)or 5%(Iso).MAP,HR,SEF and BI were recorded ,the plasma catechlamine concentration were determined using modifications of fluorimetric assay. Results SEF and BI declined in dose-dependent way in two groups ,no significant changes occurred in EEG between group A and group B.HR,MAP and catecholamine concentrations transiently increases in group A at 1.5 MAC. Conclusion A rapid increase in the end-tidal concentration of desflurane to 1.5 MAC transiently increases heart tates arterial blood pressure and circulating catecholamine concentration. [更多还原