【摘要】 １９８８～１９８９ 年在东非索马里南部对恶性疟现症患者用复方苯芴醇治疗２６ 例和氯喹治疗 １４ 例，以退热时间、原虫无性体转阴时间和随访２８ ｄ 治愈率等指标评价疗效。结果表明，复方苯芴醇和氯喹相比，退热时间相当，而原虫无性体转阴时间和随访２８ ｄ 治愈率，前者明显优于后者。前者治疗３ 例抗氯喹恶性疟患者均治愈。无免疫力患者的退热时间较有免疫力者慢，但原虫转阴时间和随访 ２８ ｄ 治愈率，两者相当；对配子体的杀灭效果不甚理想。本研究结果为复方苯芴醇在非洲恶性疟流行地区的临床应用提供了参考资料。更多还原

【Abstract】 The compound tablet of benflumetol consists of benflumetol 120 mg and artemether 20 mg(ratio 6∶1). Twenty six patients with falciparum malaria in Somalia were treated with the compound tablet of benflumetol and fourteen patients were treated with chloroquine diphosphate tablet. The result revealed that the therapeutic effect of benflumetol compound was superior to that of chloroquine. The effect of benflumetol compound was similar to patients with or without immunity. Three patients resistant to chloroquine were cured by the compound, but the gametocytes in blood of 2 patients were not eliminated within 96 hours. This study indicated that the compound tablet of benflumetol was suitable for the patients with falciparum malaria either resistant to chloroquine or not in Somalia, Africa.更多还原