【摘要】 目的探讨氯喹提高胰岛素敏感性的作用机理。方法在高脂肪饮食喂养法复制的胰岛素抵抗（IR）大鼠模型中，观察大鼠的胰岛素敏感性的变化以及氯喹对其影响。结果IR大鼠与正常大鼠相比，骨骼肌2-脱氧葡萄糖（2-DG）摄取值和正常血糖钳夹技术测定的葡萄糖输注率（GIR）显著下降；肝脏胰岛素降解活性（LIA）、空腹血浆胰岛素（FINS）及血脂则显著升高。而在高脂肪饮食喂养同时服用氯喹的大鼠与IR大鼠相比，GIR和2-DG摄取值明显上升，LIA，FINS和部分血脂指标明显下降。结论氯喹能明显提高大鼠的胰岛素敏感性，并对IR的发生、发展有一定的阻止作用。更多还原

【Abstract】 Objective To investigate the mechanism of chloroquine improving insulin sensitivity.Methods The changes in insulin sensitivity and the effects of chloroquine were observed in insulin-resistant (IR) rats induced by high-fat feeding. Results In IR rats, the glucose infusion rate (GIR) determined by euglycemic clamp and 2-deoxyglucose (DG) uptake in the skeletal muscle were lower than those in normal rats, but the activity of insulin degradation of liver (LIA), fasting plasma insulin (FINS) and plasma lipids were higher. In the high -fat fed rats with chloroquine administration, GIR and 2-DG uptake in the skeletal muscle were increased, and LIA, FTNS and some plasma lipid indices were decreased compared with the IR rats. Conclusion Chloroquine can improve the insulin sensitivity and hamper the onset and development of insulin resistance.更多还原