【摘要】 目的　探讨降纤酶治疗血栓性脑梗死的疗效。方法　将易卒中型肾血管性高血压大鼠 ,用光化学法复制成一侧大脑中动脉血栓形成后 ,分别于 3、6、9、12小时及 3、7天静脉注射降纤酶 ,并用生理盐水处理同期对照组。各组均在用药 3天后处死 ,用HE和TTC染色 ,观察大脑中动脉(MCA)内血栓及梗死灶情况。结果　治疗组的MCA内血栓溶解 ,在 3小时达 8/ 8只 ,6小时为 6/ 8只 ,9小时仅 1/ 8只 ,大于 12小时的 3组与生理盐水对照组一样血栓均未溶解情况是 :治疗各亚组的梗死灶明显小于对照组 ,在梗死灶及边缘区均无出血。结论　降纤酶能缩小梗死灶 ,在大脑中动脉闭塞的6小时内还有溶栓作用 ,且无出血并发症。更多还原

【Abstract】 Objective To investigate the effects of intravenous injection of defibrinogenase on dissoliving dissolve thrombus and salvaging cerebral infarction in stroke prone renovascular hypertension rats (RHRSP) with middle cerebral artery occlusion(MCAO) Methods The MCAO in RHRSP was induced by administration in photosensitive dye, rose bengal, and irradiation of the main MCA with a focus laser beam The thrombus in MCA and cerebral infarction were examined microscopically in HE stained sections. Infarction size was determined in triphenyltetrazolium chloride stained sections Defibrinogenase was injected intravenously at 3, 6,9, 12 hours and 3, 7 days after MCAO, meanwhile the control group received normal saline All rats were killed at 72 hours and evaluated by pathological methods after treatment Results In the treatment group, the thrombi were dissolved totally at 3 hours after MCAO, 75% at 6 hours, 13% at 9 hours Defibrinogenase failed to dissolve thrombus beyond 12 hours after MCAO, just as control group In comparison with the control group, defibrinogenase significantly reduced infarction size There was no evidence of hemorrhage Conclusions Defibrinogenase can reduce infarction size and dissolve thrombus in 6 hours after MCAO without the side effect of hemorrhage更多还原