【摘要】 目的　比较硝苯地平控释片与 5 单硝异山梨醇酯对稳定性心绞痛的疗效。方法　 5 3例稳定性心绞痛患者停用抗心绞痛药物 1周 ,然后经 2～ 3周的单盲安慰剂治疗后 ,进入为期 6周的单盲随机对照试验 ,以平板运动负荷心电图为考察指标。结果　经过 6周的治疗后 ,硝苯地平控释片( 3 0mg ,每日 1次 )与 5 单硝异山梨醇酯 ( 2 0mg ,每日 2次 )均能显著减少心绞痛发作次数 (分别下降87%和 5 1% ,P <0 0 5 )及硝酸甘油消耗量 (分别下降 91%和 5 4 % ,P <0 0 5 ) ;提高运动能力 ,延长运动时间 (分别延长 114秒和 2 5秒 ,P <0 0 1) ,且对运动能力的改善作用分别在末次服药 (疗程结束 )后 2 4小时和 12小时仍然存在。结论　硝苯地平控释片和 5 单硝异山梨醇酯均能有效改善稳定性心绞痛患者的临床症状 ,心电图及运动能力 ,其有效作用分别持续 2 4和 12小时。更多还原

【Abstract】 Objective To assess the efficacy of nifedipine gastrointestinal therapeutic system (nifedipine GITS) and isosorbide mononitrate (ISMN) in patients with stable angina pectoris Methods After withdrawing the anti angina drugs for one week, 53 patients with stable angina pectoris received placebo single blindly for 2 3 weeks, and then entered the study using a randomized, single blind design to compare the effects of nifedipine GITS and ISMN on treadmill exercise tolerance test during a 6 week period Results Both nifedipine GITS, 30mg, once daily and ISMN, 20mg, twice daily reduced angina pectoris attacks ( 87% and 51%, respectively, P <0 05) and nitroglycerin consumption ( 91% and 54%, respectively, P <0 05); improved the parameters of treadmill exercise tolerance test with prolonging the total exercise time (114 and 25 seconds, respectively, P <0 05), and the improvements were last at least 24 and 12 hours after nifedipine GITS and ISMN administrated, respectively Conclusion Nifedipine GITS as well as ISMN is able to ameliorate clinical symptoms, ischemic changes in electrocardiogram and exercise tolerance tests The beneficial effects of nifedipine GITS is over 24 hours and ISMN, over 12 hours更多还原