【摘要】 目的探讨原癌基因ＲＥＴ与先天性巨结肠发生的关系。方法应用ＰＣＲＳＳＣＰ银染技术对３０例先天性巨结肠原癌基因ＲＥＴ第１７外显子进行检测。结果发现１例家族性先天性巨结肠ＲＥＴ基因突变。结论ＲＥＴ基因突变与家族性先天性巨结肠症的发生有关。更多还原

【Abstract】 Objective To investigate the relationship between RET proto oncogene and the pathogenesis of Hirschsprung′s disease. Method Exon 17 of RET proto oncogene from 30 children with Hirschsprung′s disease was detected by PCR SSCP method. Result An abnormal pattern of DNA migration was found in a frmilial Hirschsprung′s disease. Conclusion Mutation of RET proto oncogene might play an role in the familial Hirschsprung′s disease.更多还原