【摘要】 目的　观察外源性１ ，６二磷酸果糖（ Ｆ Ｄ Ｐ） 用于心脏停搏液，对心脏直视术期间心肌缺血的保护作用。方法　将１６ 例心脏瓣膜置换术患者随机分成 Ｓｔ ． ＴｈｏｍｓⅡ号停搏液组（ 对照组） 及 Ｆ Ｄ Ｐ停搏液组（ 实验组） 。观察两组不同停搏液灌注后病人心肌酶 Ｃ Ｐ Ｋ、心肌肌钙蛋白 Ｔ（ Ｃ Ｔｎ Ｔ） 的动态变化、术中心脏停搏情况、术后心脏复苏及血流动力学状况。结果　 Ｆ Ｄ Ｐ 停搏液组血清 Ｃ Ｐ Ｋ、 Ｃ Ｔｎ Ｔ 水平明显低于对照组。 Ｆ Ｄ Ｐ 加入停搏液能显著降低冠状静脉窦流出液 Ｍ Ｄ Ａ 的含量，心脏超微结构保存较好，术中心脏诱导停搏时间短，术后心脏复苏好，血流动力学稳定。结论　外源性 Ｆ Ｄ Ｐ 用于心脏停搏液，有明显的心肌保护效果。更多还原

【Abstract】 Objective To observe the protective effects of exogenous fructose 1,6 diphosphate (FDP) in cardioplegic solution during cardiac surgery. Methods Sixteen valvular replacement patients were divided randomly into group A given St. Thomas Ⅱ solution and group B given FDP solution respectively. The changes in the serum levels of CPK, cTnT and the contents of SOD and MDA from the effluence of coronary sinus were observed. The ultrastructural changes, and the postoperative cardiac resuscitation and hemodynamic status were analyzed. Results As compared with group A, FDP could significantly alleviate the increase of CPK and cTnT levels, reduce the MDA content, maintain a better structural preservation, promote better rehabilitation and maintain better hemodynamic status after cardiac surgery. Conclusion Exogenous FDP added into cardioplegic solution has a better cardiac protective effect.更多还原