【摘要】 目的　探讨脑过度灌注的机制和防治措施。方法　应用 Ｌ Ｄ Ｆ 监测不同实验条件下大鼠脑盗血模型脑微循环血流动力学变化。结果　（１） 亚急性和慢性脑盗血纠正后 Ｌ Ｄ Ｆ 值上升６０ ％～８０ ％ ，连续监测（４５ ．５ ±４ ．０１） 分钟无下降。（２） Ｍ Ａ Ｂ Ｐ 突破脑血管自动调节阈后实验侧 Ｌ Ｄ Ｆ 值升幅为（２０５ ．８６ ±１０ ．３９） ％ 。（３） Ｐａ Ｃ Ｏ２ 升至（４９ ±６ ．７） ｍ ｍ Ｈｇ ， Ｌ Ｄ Ｆ 曲线抬高至（１４６ ．８１ ±１３ ．３９） ％ 。（４） 苯巴比妥麻醉组 Ｌ Ｄ Ｆ 升幅低（ Ｐ＜ ０ ．０１） 。（５） 应用激素和巴比妥麻醉两组 Ｂ Ｂ Ｂ破坏轻（ Ｐ ＜ ０ ．０１） 。结论　脑盗血大鼠３ 周起实验侧出现脑血管自动调节功能障碍，盗血纠正后短期内不能恢复。巴比妥麻醉、系统动脉压降压、过度通气以及糖皮质激素均有助于脑过度灌注的防治。更多还原

【Abstract】 Objective To investigate the mechanism and prevention and treatment of cerebral luxury perfusion syndrome in rats. Methods The laser Doppler flowmetry (LDF) was used to monitor the hemodynamic alterations of cerebral microcirculation in various experimental conditions in the cerebral steal model of rats. Results The increasing amplitude of the rCBF value LDF was increased by 60% to 80% after correction of subacute and chronic cerebral steal and the continuous monitoring of (45.5±4.01) min showed no decrease. After the MABP exceeding the hypertension breakthrough threshold, the value of LDF was increased by (205.86±10.39)% in the blood steal side. Following the increase of PaCO 2 to (6.5±0.9) kPa, the LDF curves elevated (146.81±13.39)%. The increasing amplitude of the rCBF value LDF in barbiturate anesthetic group was lower than non barbiturate anesthetic groups (P<0.01). The BBB disruption in barbiturate anesthetic and glucocorticoid groups was milder than that of other groups (P<0.01). Conclusion The vessel behaves intact autoregulatory mechanism in subacute and chronic blood steal brain. Barbiturates, controlled hypotension, hyperventilation and administration of steroids could do prevent and cure the BBB disruption, which resulted from luxury perfusion.更多还原