【摘要】 目的研究腺苷对猪横行腹直肌肌皮瓣成活率的影响。方法横行腹直肌肌皮瓣以左侧腹壁下动脉为供血血管,肌蒂宽6cm,皮瓣面积8cm×30cm。20头猪分为生理盐水对照组和1mg、2mg、5mg 腺苷注射实验组,掀起皮瓣前从腹壁上动脉注射不同剂量的腺苷和生理盐水。术后7天注射荧光素,以模片法记录腹直肌同侧皮瓣、对侧皮瓣和整个皮瓣的成活率。结果 2mg 和5mg 腺苷注射组,肌皮瓣成活率明显高于生理盐水对照组(P<0.05)。结论小剂量术中局部使用腺苷可增加猪横行腹直肌肌皮瓣成活率。更多还原

【Abstract】 Objective The aim of this experiment was to investigate the adenosine treatment for augmentation of TRAM flap viability in pigs.Methods This TRAM flap model was based on the deep in- ferior epigastric vascular pedicle,with the center of the transverse skin pedicle attached to the underlying rectus abdominis muscle at the superior end of the muscle and extending bilaterally from its attached mus- cle.The transverse skin pedicle(6×30cm)included a contralateral and ipsilateral random portion of skin. Prior to raising the TRAM flap,lmg,2rag or 5mg adenosine was injected through the superior epigastric artery in the experiment group.Results Treatment with 2mg or 5mg adenosine increased skin viability of the transverse skin flap in the experiment group compared with the sham-operated control(P<0.05,n= 5).Conclusion Adenosine treatment through a dominant vascular pedicle prior to raising the TRAM flap is effective in augmenting skin viability of the flap.更多还原