【摘要】 目的探讨烧伤对垂体—睾丸轴功能的影响。方法采用 RIA 法测定了28例男性烧伤患者伤后30天内血清卵泡生成素（FSH）、黄体生成素（LH）、睾酮（T）及雌二醇（E₂）水平的动态变化。结果烧伤后血清 FSH、LH、T 水平明显降低,伤后2周左右开始有所回升,而 BSA>30％TBSA 两组患者,伤后30天仍未完全恢复正常水平;E₂水平伤后明显增高,尔后逐步下降至正常水平;死亡组平均 T 水平显著低于存活组,平均 E₂水平显著高于存活组。结论烧伤后垂体功能本身可能受抑制,E₂、T 之间的失衡有可能参与烧伤免疫抑制过程,E₂、T 水平变化幅度随烧伤严重程度增加而加剧,是反映烧伤程度较为敏感的指标。更多还原

【Abstract】 Objective To investigate the effects of burn trauma on pituitary-testis axis.Methods The changes in serum estradiol （E₂）,testosterone （T）,luteinizing hormone （LH）,and follicle stimulating hormone（FSH） levels were dynamically investigated by RIA in 30 days after thermal injury in 28 burnt men.Results The serum FSH,LH,and T levels significantly decreased after injury,and there was some increase from PBD（postburn day） 14 to 30.In patients in group Ⅱ and Ⅲ （BSA>30% TBSA）,not all of their FSH,LH,and T levels reached the normal control on the PBD 30.Serum E₂ levels were elevated af- ter injury,then returned gradually to normal.In three patients who died,their mean T levels were signifi- cantly lower than patients who survived,but mean E₂ levels were significantly higher than that of sur- vivors.Conclusion The activity of pituitary might be depressed after burn trauma.The imbalance be- tween E₂ and T might play a role in the processes of immuno-depression after injury.The changed extent of E₂ and T levels was correlated to burn size.They could be sensitive indicators of burn stress.更多还原