【摘要】 目的　探讨血小板活化、凝血激活与不稳定性心绞痛 (UA)的关系及其临床意义。方法　用酶联免疫双抗体夹心法分别测定 2 2例UA患者急性期和缓解期血浆α 颗粒膜蛋白 (GMP 14 0 )、D 二聚体浓度 ;并用相同方法测定 18例稳定劳累型心绞痛 (SA)患者和 2 0例健康对照者上述指标 ,对其结果进行统计学分析。结果　UA患者急性期血浆GMP 14 0、D 二聚体浓度显著高于SA组 (P <0 0 1)和对照组 (P <0 .0 1) ,后两组之间差异无显著性 (P >0 .0 5 ) ;UA患者缓解期血浆GMP 14 0、D 二聚体水平较其急性期有所下降但差异无显著性 (P >0 .0 5 ) ,并仍显著高于SA组 (P <0 .0 5 )。结论　结果提示血小板活化、凝血激活系统及内皮细胞损伤在UA的发生发展中起重要作用。更多还原

【Abstract】 Objective To explore the relationship between platelet activation and enhanced coagulability and the occurrence unstable angina. Methods Plasma levels of a granule membrane protein (GMP 140) and fibrin D dimer were measured in 22 patients with unstable angina during the acute phase and after relief. The same procedure were compared with those in 20 control subjects and 18 patients with stable angina. Results Plasma levels of GMP 140 and D dimer were significantly higher in patients with unstable angina both during the acute phase( P <0.01) and after the relief ( P <0.05) as compared with those in control subjects and patients with stable angina, but there was no significant difference between the latter two groups ( P >0.05). There was also no significant difference between the patients with unstable angina during the acute phase and after the relief ( P >0 05). Conclusion It is shown that activation of platelet and coagulation system combined with endothelial injury may play an important role in the development of unstable angina.更多还原