【摘要】 目的　研究单纯性肥胖病人空腹和餐后血浆β内啡肽（β Ｅｐ） 水平变化。方法　２０ 例肥胖症患者和１２ 例正常对照组在隔夜空腹后，于试餐前及餐后３０ 分钟、６０ 分钟、１２０ 分钟和１８０ 分钟采血６ ｍｌ，用放射免疫法测定血浆β Ｅｐ 、胰岛素、皮质醇和 Ａ Ｃ Ｔ Ｈ 水平。结果　肥胖组基础血浆β Ｅｐ 和胰岛素水平明显高于对照组（ Ｐ＜ ０ ．００１ 和０ ．０１） ，肥胖组基础血浆β Ｅｐ 与 Ｂ Ｍ Ｉ无相关性（ ｒ ＝ ０ ．１０３ ， Ｐ＞ ０ ．２０） ，肥胖组β Ｅｐ 曲线下面积与 Ａ Ｃ Ｔ Ｈ 曲线下面积无相关性（ ｒ ＝ ０ ．１３２ ， Ｐ＞ ０ ．０５） 。结论　高β Ｅｐ 血症可能是与肥胖特征有关的一种现象，可将β Ｅｐ 做为肥胖症诊断的实验室参考指标之一，但不能将β Ｅｐ 作为反映肥胖症程度的指标。更多还原

【Abstract】 Objective To investigate the fasting and postprandial plasma β endorphin (β Ep) levels in patients with simple obesity. Methods 20 obese patients and 12 healthy volunteers entered this study. The plasma levels of β Ep, insulin, cortisol and ACTH at 0’、30’、60’、120’and 180’ after oral mixed test meal (OMTM) were measured by RIA. Results Fasting plasma β Ep and insulin levels were significantly higher in patients with obesity than those in controls. Plasma β Ep levels were not correlated with BMI in obese patients (r=0.103,P>0.20). There was no correlation between the areas under the curves of serum β Ep and ACTH (r=0.132,P>0.05).Conclusion The increase in the β Ep levels might be a phenomenon in simple obesity. Serum β Ep level may serve as a reference parameter in diagnosing obesity, but it can not reflect the degree of obesity.更多还原