【摘要】 目的观察肾上腺素对１％罗哌卡因硬膜外阻滞的药效学和药动学影响。方法选择ＡＳＡⅠ～Ⅱ级行下腹部手术病人１６例，随机分为两组，每组８例。分别用１％罗哌卡因２ｍｇ· ｋｇ~－１（Ｒ组）和加入１： ２００ ０００肾上腺素的 １％罗哌卡因 ２ｍｇ· ｋｇ~－１（ＲＥ组）行硬膜外阻滞，对比两组药效学和药代动力学指标。结果两组药效学指标、Ｃｍａｘ和ＡＵＣ间均无显著性差异。与Ｒ组相比，ＲＥ组的Ｔｍａｘ明显后延（Ｐ＜０．０１），Ｋ值明显降低（Ｐ＜０．０５）。结论 １：２００ ０００肾上腺素对１％罗派卡因硬膜外阻滞的药效学没有影响，但可以减缓罗哌卡因的吸收和清除。更多还原

【Abstract】 Objective To determine the pharmacokinetics and pharmacodynamics of ropivacaine used with or without epinephrine for epidural blockade. Methods Sixteen ASA physical status Ⅰ or Ⅱ adult patients undergoing elective lower abdominal surgery, were randomly divided into two groups, in group R (n=8) epidural blockade was induced with 1% ropivacaine 2mg. kg-1 without epinephrine, while in group RE (n=8) with 1% ropivacaine Zing· kg-1 with 1: 200 000 epinephrine. The onset time, the duration of analgesia and motor blockade degree of both groups were observed and plasma concentrations of ropivacaine of both groups were measured with gas chromatography. Results There were no significant differences in pharmacodynamic parameters, peak plasma concentration and area under the plasma concentration-time curve between both groups. The time to peak plasma concentration in group RE was longer than that in group R (P<0. 01). The elimination rate constant of group RE was lower than that of group R (P<0.05). Conclusion Addition of epinephrine can not affect the pharmacodynamics of epidural 1% ropivacaine, but the absorption and elimination rates of which is reduced.更多还原