【摘要】 目的　比较阿芬太尼和艾司洛尔对气管插管时循环及儿茶酚胺反应的影响。方法　 35例病人随机分为 3组 ,A组为对照组 ,B组为艾司洛尔组 ,C组为阿芬太尼组。插管前 B、C组分别给予2 mg/ kg艾司洛尔、30μg/ kg阿芬太尼。静注硫喷妥钠和维库溴铵诱导插管。结果　插管后 3分 ,阿芬太尼组收缩压显著降低 (P<0 .0 1) ,B、C两组的心率低于对照组 (P<0 .0 5 )。 A、B两组的血浆去甲肾上腺素浓度 (NE)增加 ,均高于其基础值 (P<0 .0 1) ,但阿芬太尼组 NE水平无明显改变 ,肾上腺素水平较基础值降低 (P<0 .0 1)。结论　艾司洛尔 2 mg/ kg可在一定程度上缓解插管时的循环反应。阿芬太尼 30μg/ kg能完全抑制插管时的循环及儿茶酚胺反应。更多还原

【Abstract】 Objective To compare the effect of alfentanil and esmolol on hemodynamic and catecholamine response to tracheal intubation Methods Thirty five adult patients were randomly allocated into one of three groups:A group (control group),B group (esmolol group) and C group (alfentanil group) The patients received 2 mg/kg esmolol in B group and 30 μg/kg alfentanil in C group before intubation Tracheal intubation was performed with 4 mg/kg thiopental and 0 1mg/kg vecuronium and 3% isoflurane Systolic pressure (SР),heart rate (HR),plasma norepinephrine (NE),epinephrine (E) and dopamine (DA) concentrations were measured with high performance liquid chromatography before and after intubation Results SP in C group 3 min after intubation was significantly lower than the baseline (P<0 01) HR in B group 2 min after intubation increased significantly but HR in B and C groups 3 min after intubation were significantly lower than that in control group (P<0 05) NE level in A and B groups increased significantly 3 min after intubation (P<0 01) NE level in C group 3min after intubation was not significantly different from the baseline but E level decreased significantly (P<0 01) Conclusion 2 mg/kg esmolol can reduce hemodynamic response to intubation to a certain extent and 30μg/kg alfentanil can completely attenuate the hemodynamic and catecholamine responses更多还原