【摘要】 目的　观察分析高压氧（ＨＢＯ）治疗及常规治疗新生儿缺氧缺血性脑病（ｈｙｐｏｘｉｃ ｉｓｃｈｅｍ ｉｃｅｎｃｅｐｈａｌｏｐａｔｈｙ，ＨＩＥ）的疗效。方法　ＨＢＯ治疗组４８例，给予ＨＢＯ及常规护脑、对症治疗；治疗绝对压为０．１３～０．１５ ＭＰａ，氧浓度为６５％ ～９０％ ，每次６０～８０ 分钟（以上３ 项条件视年龄大小而异），每天治疗１ 次，１０ 次为１ 个疗程，一般为１～２ 个疗程。常规治疗组４１ 例，给予常压下吸氧及同样护脑、对症治疗。结果　ＨＢＯ治疗组疗效为：显效１８ 例（３７．５％ ），有效２７ 例（５６．２５％ ）、无效３ 例（６．２５％ ），总有效率为９３．７５％ 。常规治疗组疗效为：显效８ 例（１９．５１％ ），有效２４例（５８．５４％ ）、无效９ 例（２１．９５％ ），总有效率为７８．０５％ 。两组显效率相比较，χ２ ＝ ３．８８　Ｐ＜ ０．０５；总有效率相比较，χ２ ＝ ４．７４　Ｐ＜ ０．０５，均有显著差异性。结论　对ＨＩＥ治疗的ＨＢＯ 治疗组疗效优于常规治疗组。更多还原

【Abstract】 Objective To observe and analyse the effect of hyperbaric oxygen(HBO) therapy on hypoxic ischemic encephalopathy(HIE) of neonates. Methods 48 patients in the HBO therapy group were treated with HBO plus routine therapy including protection of the brain and symptomatic treatments. The conditions of HBO therapy were 0 13~0 15 MPa, oxygen concentration 65%~90% and 60~80 min in one treatment varied according to the patients′ age. The HBO was given once daily and 10 times as one course for 1~2 courses generally. 41 patients in the routine therapy group were treated likewise but without HBO(with normal pressure oxygen inhalation). Results The outcomes of HBO group were: marked effect in 18 cases(37 5%), positive effect in 27 cases(56 25%) and no effect in 3 cases(6 25%) with a total effective rate(marked plus positive effects) of 93 75%; while that of routine therapy group were: marked effect in 8 cases(19 5%), positive effect in 24 cases(58 54%) and no effect in 9 cases(21 95%) with a total effective rate of 78 05%. The marked effective rates between the two groups were statistically significant( χ 2=3 38 P <0 05); and the total effective rates of them were also statistically significant( χ 2=4 74 P <0 05). Conclusions The effect of treatment of HIE with HBO plus routine therapy is better than that of routine therapy alone.更多还原