【摘要】 目的研究肝脏炎性疾病患者血浆中组织因子途径抑制物（ＴＦＰＩ）与抗凝血酶Ⅲ（ＡＴ－Ⅲ）的改变及其临床意义。方法ＴＦＰＩ抗原（ＴＦＰＩ：Ａｇ）采用双夹心ＥＬＩＳＡ抗原测定法，ＴＦＰＩ活性（ＴＦＰＩ：Ａ）采用发色底物法，ＡＴ－Ⅲ：Ａｇ采用免疫浊度法，ＡＴ－Ⅲ：Ａ采用发色底物法。结果急性中毒性肝炎１４例，急性病毒性肝炎２０例，慢性乙型肝炎４８例，共８２例肝脏炎性疾病患者ＴＦＰＩ：Ａｇ与ＴＦＰＩ：Ａ均高于正常值（Ｐ＜０．０５，Ｐ＜０．０１），ＡＴ－Ⅲ：Ａｇ均接近正常值，ＡＴ－Ⅲ：Ａ除慢性乙肝中度低于正常值外，其余接近正常值。结论肝脏炎性疾病ＴＦＰＩ均上调，表明组织受损，炎症存在。而ＡＴ－Ⅲ可正常或降低，表明肝细胞分泌ＡＴ－Ⅲ有一定程度减少。更多还原

【Abstract】 To inVedigut6 the Chadal and clinical sghcance of tissue factor pathway inhibitor (TFPI) and afltithrombin--ill (AT--ill) in the Plasma of patientS with heDatic inflammatory disease (HID).Methods The plasma levels and activation of TFPI and AT--ill in P8tientS with HID (Group i, n=82) werecompared to that in healthy people (Group 11 as control, n=30). R~ The plasma level of TFPI4Ag inGroup I was higher (P<0.05) and itS aCtivation was also increase dramatically (p<0.ol), the level of AT--ill:A was lower in patientS with chronic hepatitis B (P<0.05) and no difference was found in other indicesbetween the tWo groupe. Conchaons Tit6 elevation of TFPI:Ag and TFPI:A in hepatic inflammatory dibeaasis an indication of inflammation, and heP8tic tissue injury in broad, the lower level of AT--ill liver secretions.更多还原