【摘要】 目的了解掌腱膜挛缩症（Ｄｕｐｕｙｉｒｅｎ挛缩）的病理表现。方法采用免疫组化染色辅以计算机图像定量分析技术，对１５例掌腱膜挛缩症患者的门侧病变掌腱膜及９例正常掌腱膜组织标本中的Ⅰ、Ⅲ型胶原和α－平滑肌肌动蛋白的表达进行检测，并用透射电镜观察病变掌腱膜组织的超微结构。结果病变掌腱膜组织中Ⅰ型胶原的表达低于正常对照组（Ｐ＜０．０５）；Ⅲ型胶原在病变组织中的表达略高于对照组（Ｐ＞００５）；α－平滑肌肌动蛋白在病变组织中的表达明显高于对照组（Ｐ＜０．０１）。在病变掌腱膜组织中存在有一种特化的肌纤维母细胞。结论肌纤维母细胞是掌腹膜挛缩症发病中最关键的病理因素。更多还原

【Abstract】 Objective To investigate the pathological changes of Dupuytren’s disease. MethodsStreptoavidin Peroxidase methods were applied to determine the expression level of type Ⅰ, Ⅲ collagen andα-SM actin in 17 hands of 15 patients and 9 hands of control samples of palmar aponeurosis. The ultrastructureOf lesioned aponeurosis was examined with electron microscope. Results The expression of type I collagenin the lesion was lower than that in normal aponeurosis (P < 0. 05), type Ⅲ collagen in the lesion was slightlyhigher than that in normal (P > 0. 05), and α-SM actin in the lesion was significantly higher than that innormal (P < 0. 01 ). There was a modified fibroblast (myofibroblast) in the lesioned aponeurosis. ConclusionMyofibroblasts aPPeared to be the most important factor in the pathogenesis of Dupuytren’s contracture.更多还原