【摘要】 目的探讨结合雌激素（ＣＥ）和７甲基异炔诺酮（ＯｒｇＯＤ１４）对围绝经期和绝经期妇女脂蛋白及载脂蛋白的影响。方法７４例围绝经期和绝经期患者分为：（１）ＣＥ组４６例，其中围绝经期１７例，绝经期２９例，按连续序贯方案每日口服ＣＥ０．６２５ｍｇ，每日醋酸甲孕酮４ｍｇ；（２）ＯｒｇＯＤ１４组２８例，其中围绝经期９例，绝经期１９例，口服ＯｒｇＯＤ１４２．５ｍｇ，隔日１次。两组分别连续治疗２年，于用药前、用药１年、２年取静脉血测定血脂蛋白、载脂蛋白、雌二醇、促卵泡激素水平。结果ＣＥ组用药后总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬＣ）、载脂蛋白ＡＩ（ＡｐｏＡＩ）、载脂蛋白ＡＩ（ＡｐｏＡＩ）、载脂蛋白Ｂ（ＡｐｏＢ）、载脂蛋白ＣＩ（ＡｐｏＣＩ）、载脂蛋白ＣＩＩ（ＡｐｏＣＩＩ）、脂蛋白（ａ）［Ｌｐ（ａ）］明显升高，ＡｐｏＢ／ＡＩ、ＡｐｏＣＩ／ＣＩＩ比值显著下降。ＯｒｇＯＤ１４组ＡｐｏＣＩＩ、ＡｐｏＥ显著下降，ＡｐｏＡＩ／ＡＩ比值显著升高，其中ＡｐｏＥ用药２年较用药１年有显著下降。两组ＬＤＬＣ无显著性变化。用药１年时，ＣＥ组ＴＣ、ＨＤＬＣ、ＡｐｏＡＩ、ＡｐｏＣＩＩ、ＡｐｏＥ显著高于ＯｒｇＯＤ１４组（Ｐ＜０．?更多还原

【Abstract】 Objective To determine the effect of conjugated estrogen and Org OD14 on serum lipoprotein and apolipoprotein in perimenopausal women. Method 74 patients were divided into 2 groups: 46 were given conjugated estrogen 0.625 mg and medroxyprogesterone acetate 4 mg daily according to the continuous sequential. regimen 28 were given Org OD14 2.5 mg every two days. Serum lipoprotein and apolipoprotein estradiol and follicle stimulating hormone were measured before and (one and two years) after treatment. Results Total Cholesterol(TC), Triglycerin(TG), high density lipoprotein(HDLC), Apolipoprotein AI( Apo AI), Apolipoprotein AII (Apo AII), Apolipoprotein B(Apo B), Apolipoprotein CII(Apo CII), Apolipoprotein CIII(Apo CIII), Lipoprotein(a) increased significantly (P<0.05), while ApoB/AI, ApoCII/CIII decreased significantly(P<0.05) in conjugated estrogen group. ApoCIII, E decreased, while ApoAI/AII increased significantly (P<0.05) in Org OD14 group. After two years treatment, TC, HDLC, ApoAI, ApoCIII,ApoE, TC, HDLC, ApoAI, ApoCIII, ApoE of conjugated estrogen group were higher than those of Org OD14 group(P<0.05), ApoCII/CIII of Conjugated estrogen was lower than that of Org OD14 group(P<0.05). Conclusion Postmenopausal hormone replacement therapy regulates the constitution of serum lipoprotein and apolipoprotein.更多还原