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妊高征患者血清抗中性粒细胞胞浆抗体的检测及临床意义
Detection of Antineutrophil Cytoplasmic Autoantibodiesin PregnancyInduced Hypertension andIts Clinical Significance
【摘要】 目的 探讨妊高征患者血清抗中性粒细胞胞浆抗体(ANCA) 的表达及其在妊高征发病中的作用。方法 用间接免疫荧光方法检测37 例妊高征患者( 妊高征组) 和39 例同期非妊高征孕妇(对照组)血清中ANCA 的表达。结果 妊高征组轻、中、重度妊高征患者ANCA 的阳性率分别为33-3% 、88-9% 、86-4 % ,其分型以细胞质荧光染色型(cANCA) 为主,对照组ANCA 阳性率为13-2% ,明显低于妊高征组( P< 0-001) 。结论 ANCA阳性率增加可能是妊高征患者血管内皮细胞损伤的原因之一,ANCA可作为妊高征的监测指标之一。
【Abstract】 Objective To explore the level of antineutrophil cytoplasmic autoantibodies(ANCA) in patients with pregnancyinduced hypertension (PIH) anditsclinicalsignificance- Method 37 cases with PIHand 39 non PIHpregnancy were studiedfor ANCAbyindirectimmunflourscence- Results ANCApositive rates were 33-3% ,88-9% and 86-4% in mild,moderate,severe PIH,respectively,and mostofthem werec ANCA- The positiverate wasonly13-2 % in non PIHcontrol,significantlylowerthanthosein PIH(P<0-001)- Conclusion ANCAmay be one ofthe causesforendothelialcelldamageand a predicting markerin PIH-
【Key words】 Pregnancy complications; cardiovascular Hypertension Antibodies; antineutrophil cytoplasmic autoantibodies;
- 【文献出处】 中华妇产科杂志 ,Chinese Journal of Obstetrics And Gynecology , 编辑部邮箱 ,1999年12期
- 【分类号】R714.24
- 【被引频次】6
- 【下载频次】45