【摘要】 目的　探讨羊水内皮素１（ＥＴ１） 与围产儿缺氧的关系。方法　采用放射免疫法对１６１例孕（ 产）妇进行羊水ＥＴ１ 水平检测。将其分为正常妊娠组１１０ 例，对其中足月妊娠３０ 例同时进行母血和脐血ＥＴ１ 水平检测；宫内缺氧组５１ 例。结果　（１） 羊水ＥＴ１ 水平在正常妊娠组孕１４ ～２７ 周时为（７．７４０±２ ．１３３）ｎｇ／Ｌ，至妊娠晚期时为（１８．６４０ ±１ ．９６８）ｎｇ／Ｌ，随孕周增加呈上升趋势（ Ｐ＜ ０．０１） 。（２） 脐血ＥＴ１ 水平明显高于母血ＥＴ１ 水平，但较羊水为低（Ｐ＜０．０１） 。羊水与脐血ＥＴ１ 水平存在正相关关系（ｒ＝０．９５２，Ｐ＜０．０１），而母血与脐血无相关关系（ｒ＝ ０．３３８，Ｐ＞ ０ ．０５） 。（３） 宫内缺氧组中，出现胎儿窘迫者羊水ＥＴ１ 水平为（３０．６５４ ±５．８３２）ｎｇ／Ｌ，较正常妊娠组明显升高（ Ｐ＜０．０１） ；出现重度新生儿窒息死亡者羊水ＥＴ１ 水平为（９６０ ．６５０ ±２３６ ．６９８）ｎｇ／Ｌ，为正常晚期妊娠的６０ 倍左右（ Ｐ＜０ ．００１） 。结论　正常妊娠羊水中存在ＥＴ１ ，且随妊娠进展而增加。胎儿缺氧时羊水ＥＴ１ 水平升高，并随缺氧程度加重而显著上更多还原

【Abstract】 Objective To investigate the relationship between endothelin 1 (ET 1) concentration in amniotic fluid (AF) and perinatal hypoxia. Methods 161 cases were measured for amniotic fluid(AF) ET 1 levels by radioimmunoassay. 110 cases of normal pregnancy were included in control group among which 30 term pregnancies were simultaneously measured for maternal and umbilical plasma ET 1. 51 cases of intrauterine hypoxia were the study group. Results (1) The AF ET 1 levels showed increasing trend after 14 weeks ( P < 0.01). (2) Fetal plasma ET 1 levels were signifcantly higher than that of maternal plasma ET 1 levels, but lower than those of AF ET 1 ( P <0.01). The ET 1 levels of umbilical plasma had positive correlation with those of AF ET 1 ( r =0.952, P <0.01), but there is no correlation with levels of maternal plasma ET 1 ( r =0.338, P <0.05). (3) In study group, the level of AF ET 1 was elevated with severity of hypoxia, the average level of AF ET 1 in cases of intrauterine hypoxia was (30.654±5.832) ng/L. In cases of severe neonatal asphyxia it was (960.650±236.698) ng/L. Conclusions The ET 1 exists in AF and gradually increaser while pregnancy advanced. AF ET 1 levels can be served as a marker to predict perinatal hypoxia更多还原