【摘要】 目的　观察羟甲戊二酰辅酶Ａ还原酶抑制剂辛伐他汀和食物中脂类含量对阿霉素肾病大鼠肾组织损伤程度的影响。方法　对阿霉素肾病大鼠分别饲以标准及高脂鼠食并给予辛伐他汀，观察其尿蛋白排出量、血脂、血尿素氮（ＢＵＮ） 、肌酐（Ｓｃｒ）和肾脏光镜组织形态学变化。结果　首次给予阿霉素后２２ 周时，正常对照组、标准鼠食肾病对照组和治疗组、高脂鼠食对照组和治疗组大鼠尿蛋白排出量依次（下同）为：（５８±２１），（１２０ ±４１） ，（９２ ±２５） ，（４０７±３５），（２３６±５４） ｍｇ／２４ｈ（Ｆ＝ １１７－６５，Ｐ＜ ０－０１）；血甘油三酯（０－９９±０－０９），（１－４３±０－２９），（１－６１±０－３０），（２－９１±０－２５），（１－７０±０－２３） ｍｍｏｌ／Ｌ（Ｆ＝ ６８－７３， Ｐ＜０－０１）；总胆固醇（２－５３ ±０－５０） ，（３－２８ ±０－２８） ，（３－０２ ±０－５９），（４－５２ ±０－４１），（３－４２ ±０－４０） ｍｍｏｌ／Ｌ（Ｆ＝２１－５０， Ｐ＜ ０－０１） ；低密度脂蛋白胆固醇（１－５３ ±０－２１） ，（２－０２±０－０９），（１－７４±０－３６） ，（２－６７±０－２２），（１－９３±０－２２） ｍｍｏｌ／更多还原

【Abstract】 Objective To investigate the effects of high lipid diet and simvastatin on renal histological injuries in adriamycin induced nephropathy in rats Method Urinary protein, blood lipids, BUN, serum creatinine, and histological change were checked in nephropathic rats fed with regular and high lipid chow and treated with simvastatin Results At week 22, the amounts of urinary protein (mg/24h) were (58±21), (120± 41), (92±25), (407±35), (236±54) ( F= 117 65, P< 0 01); the levels of serum triglyceride (mmol/L) (0 99±0 09), (1 43±0 29), (1 61±0 30), (2 91±0 25), (1 70±0 23) ( F= 68 73, P< 0 01); total cholesterol (mmol/L) (2 53±0 50), (3 28±0 28), (3 02±0 59), (4 52±0 41), (3 42±0 40) ( F= 21 50, P< 0 01); low density lipoprotein cholesterol (LDL ch) (mmol/L) (1 53±0 21), (2 02± 0 09), (1 74±0 36), (2 67±0 22), (1 93±0 22) ( F= 26 57, P< 0 01) in normal control, regular diet control and simvastatin treated, high lipid control and simvastatin treated groups, respectively All these values were significantly higher in adriamycin treated groups than those of control groups; the values of high lipid diet control groups were also higher than those of regular diet control groups ( t= 15 18, P< 0 01; t= 10 93, P< 0 01; t= 7 06, P< 0 01; t= 5 59, P< 0 01, respectively), and in simvastatin treated groups were lower than those of corresponding control groups ( t= 7 49, P< 0 01; t= 10 07, P< 0 01; t= 7 78, P< 0 01; t= 6 73, P< 0 01, respectively) Histological study demonstrated that the percentage of glomeruli in which segmental sclerosis occurred were (3 2±1 4), (55 6±13 5), (13 6±5 0), (86 8±3 4), (37 6±25 6), respectively The differences among control and adriamycin treated groups were significant ( H= 35 1, P< 0 01); mesangial proliferation and matrix expansion significantly increased in the adriamycin treated rats, and were associated with significant tubulointerstitial injuries. The degree of glomerular injuries and extent of tubulointerstitial pathological change were more serious in high lipid diet groups than in regular diet groups; and compared with corresponding control groups, those in simvastatin treated groups were significantly less severe Conclusion In the adriamycin treated rats, high lipid diet may worsen, and simvastatin can ameliorate the renal histological injuries更多还原